Defective Virions in Human Adenovirus Type 12
نویسندگان
چکیده
منابع مشابه
Structure and function of adenovirus type 12 defective virions.
Purified human adenovirus type 12 preparations contain defective virions with a lighter density. These defective virions were isolated, and their biological functions and DNA were characterized. They can induce early and late antigens in infected cells and tumors in newborn hamsters with similar efficiency as complete virions. The majority of the DNA molecules from light virions contain deletio...
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Temperature-sensitive mutants of type 5 adenovirus belonging to eight complementation groups were complemented in mixed infection by type 12 adenovirus, whereas mutants of 7 other groups were not enhanced. In some crosses, phenotypic mixing took place. No evidence of recombination between type 5 ts mutants and type 12 was found.
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The incorporation of l-[(14)C]ornithine and [(14)C]putrescine into putrescine, spermidine, and spermine in type 5 adenovirus-infected KB cells was identical to that in uninfected control cells early in infection, but incorporation into putrescine stopped after 8 to 12 h and the rate of incorporation into spermidine was reduced between 12 and 20 h after infection. The amount of polyamines found ...
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It has been demonstrated that cellular and viral RNAs were packaged in the virions of human cytomegalovirus (CMV) and herpes simplex virus 1 (HSV 1), members of the Herpesviridae family, both of which are enveloped double-stranded DNA viruses. Here, we provide evidence suggesting that RNAs are packaged in the virions of porcine adenovirus type 3 (PAdV-3), which is a member of the Adenoviridae f...
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Recent reports relative to the oncogenicity of adenovirus types 12 and 18 (Trentin, Yabe, and Taylor, Science 137:835, 1962; Huebner, Rowe, and Lane, Proc. Natl. Acad. Sci. U.S. 48:2051, 1962) have caused a renewed surge of interest in the adenovirus group. In addition to the prototype strain Huie, Huebner and co-workers investigated eight adenovirus type 12 strains, recovered from anal swabs o...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1971
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.7.4.426-433.1971